Development of efficient solid chiral catalysts with designable linkage for asymmetric transfer hydrogenation of quinoline derivatives

Developing chiral solid catalysts for asymmetric catalysis is desirable the elimination of homogeneous flaws but remains an immense challenge. Herein, we report immo-bilization TsDPEN on SBA-15 with ionic liquid (IL) linkage via one-pot reac-tion imidazole-TsDPEN-N-Boc 3-(trimethoxysilyl)propyl bromide in mesopores. After coordination to Rh, could efficiently cata-lyze quinoline transfer hydrogenation, achieving 97% conversion 93% ee, which was comparable their counterparts. The catalyst IL afforded much higher turnover frequency than that without (93 h–1 vs. 33 h–1), attributed phase and formate-enriching ability linkage. Furthermore, effect pH reaction rate in-vestigated, preventing retardation during catalytic process. tuning group efficient approach activity improvement immobilized catalysts.